FermagalusTM

The most bioactive astragalus by a unique fermentation process
 
Conversion of the saponins to the more active deglycosylated form
Higher concentration of active substances
Formation of smaller active flavonoids or SOD-like substances
High content of cycloastragenol and calycosin
Impact on telomeres
Much lower daily dose needed

What is Fermagalus™?

Fermagalus™ is fermented astragalus, a medicinal herb used in traditional Chinese medicine. This plant grows mainly in northern China, Mongolia and Siberia. The root of astragalus is used for medicinal purposes. This immune-supporting herb is made even more potent than it already is by an innovative Biotransforming Fermentation Technology!

Astragalus contains over 126 different components, such as flavonoids, saponins, and polysaccharides as the main active substances, but also contains amino acids and phenolic acids.

The following are the most important:

  • Saponins such as astragalosides I through VII, based on the cylcoastragenol backbone

    Cylcoastragenol
  • Polysaccharides such as e.g. APS-I, APS-II and astragalin or kaempferol-3-O-b-glucoside

    Astragalin
  • Isoflavones glycosides such as calycosin-7-glucoside

    Calycosin
  • Flavonoids such as kaempferol, quercetin, isorhamnetin and rhamnocitrin


Why fermenting astragalus?

Biotransformation of secondary plant substances

Astragalus is rich in polysaccharides, saponins and flavonoids. Therefore, this plant is suitable for lactic acid fermentation since the bioavailability is significantly increased by bioconversion.

The most active components of astragalus are the astragalosides, called saponins. The main focus is on the conversion of the original glycolized saponins to the more active form through our own lactic acid fermentation.

Due to their bulky molecular structure, saponins have poor membrane permeability and are susceptible to degradation. The mass of the original astragalosides decreases after fermentation due to the removal of the sugar molecules. This process is called deglycosylation.

This results in the so-called aglycone form such as e.g. cycloastragenol, which is permeable and therefore directly bioactive. Smaller molecules, which are very active and well studied, penetrate the body more easily!

Our controlled fermentation of astragalus also results in biotransformation of isoflavone glycosides to aglycones such as e.g. the bioactive substance calycosin. Fermentation with probiotic organisms improves the bioavailability of isoflavones.

FermagalusTM contains good absorbable polysaccharides that have a regulatory effect on the immune system. They increase T-cell activity and thereby protect against pathogens such as viruses and bacteria.

Polysaccharides also increase NK (Natural Killer) cell activity, reducing the chance of unwanted cell growth (tumor formation).

The flavonoids are broken down into smaller active antioxidant molecules by fermentation

Formation of SOD-like substances that are not rapidly destroyed in the digestive tract such as superoxide dismutase (SOD) and perform the same function.

All this shows that a controlled fermentation offers a lot of added value compared to astragalus that is not fermented.

The power of cycloastragenol and calycosin

Astragalus is an eye-catching geroprotector. Telomere support is in the spotlight when it comes to slowing down the rate of aging and the onset of age-related diseases. Telomere length is a biological clock that determines the lifespan of a cell. Oxidative stress accelerates the shortening of telomeres, which can be compensated by telomerase. Astragalus (Astragalus membranaceus) is most commonly used to support immune health in chronic degenerative diseases.

In addition to the well-known astragalus polysaccharides (APS), saponins and flavonoids are two other classes of chemical compounds that are considered as quality control markers and possess multiple pharmacological properties.

Cycloastragenol (CAG), the aglycone form of astragalosides that are the major saponins of astragalus, is currently the only compound known to activate telomerase in humans.

Calycosin (CA), the major flavonoid of astragalus, is a potent antioxidant to prevent telomeres from oxidative damage. The synergistic protection of CAG and CA against telomere shortening makes astragalus a promising candidate for geroprotection.

In addition to telomere lengthening, CAG has other extensive pharmacological effects, including anti-inflammatory, antioxidant, antiviral, anti-pulmonary fibrosis, anti-ischemic and hypoxic damage, and anti-lipid accumulation properties. CA also optimizes the immune system, is anti-inflammatory, protects against osteoporosis, and has neuroprotective & hepatopro­tective properties.

The big benefit of Fermagalus™

The big benefit of Fermagalus™ is that the natural matrix of the plant is preserved. Together with the very high bioavailability of the active substances, this ingredient is much safer than those that only offer the pure, isolated form of cycloastragenol or calycosin.

The plant astragalus contains many other intelligent substances that are highly beneficial to the body, also in their best absorbable form via a patented and controlled fermentation process. It is the synergy of secondary plant metabolites in their best absorbable form that plays an important role for health!

Science

Many studies show the therapeutic properties of astragalus. It is therefore scientifically very well founded. However, it is important that the saponins are available in their easily absorbable form because this is a condition for the therapeutic power of this promising plant!

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Health benefits

  • Repair of DNA damage by activating telomerase (longevity)
  • General optimization of the functioning of the immune system
  • Has strong anti-viral properties and protects the body against colds and flu
  • Is an adaptogen and increases our adaptation to all kinds of stressful circumstances
  • Has neuroprotective properties due to the astragalosides
  • Has strong liver-supporting properties
  • Improves breathing by both strengthening the lung muscles and reducing mucus formation
  • Provides cardiovascular protection as it acts as a blood vessel dilator and slight blood thinner as well as a support for cardiac arrhythmias, respiratory distress, heart failure and heart muscle inflammation.

Legislation

Europe
Astragalus is authorized in EU for use in food supplements.

Belgium
Astragalus is a plant that appears on the list of permitted plants in Belgium. It is listed in The Royal Decree of 29 August 1997 on the manufacture and trade of foodstuffs composed or containing plants or plant preparations.

Belfrit
Astragalus is on the Belfrit list and is allowed in Belgium, France and Italy.

Fermented astragalus is obtained by fermentation, a procedure traditionally used in food production, and does not fall under Regulation (EU) no. 2015/2283 on novel foods.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA) and price quotation.

Storage
Due to the hygroscopic nature, please store at dry conditions in an airtight container. Shelf life is minimum two years at 25oC and below 70% RH in original sealed package.

MOQ (minimum order quantity) 20 kg

FormUseDosageStandardized on
PowderNutritional supplements and functional food150 - 200 mg/dayCycloastragenol > 0,2 % | Calycosin > 0,2 % | Polysaccharides > 10 % | Paraprobiotics > 20 billion CFU/g

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References

  1. Yongjie Yu, Limin Zhou, Yajun Yang, and Yuyu Liu. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep; 16(3): 2175–2182
  2. Ip FC, Ng YP, An HJ, Dai Y, Pang HH, Hu YQ, Chin AC, Harley CB, Wong YH, Ip NY. Cycloastragenol is a potent telomerase activator in neuronal cells: Implications for depression management. Neurosignals. 2014;22:52–63
  3. Mao Deng, Huijuan Chen, Jiaying Long, Jiawen Song, Long Xie & Xiaofang Li. Calycosin: a Review of its Pharmacological Effects and Application Prospects. Expert Review of Anti-infective Therapy. Volume 19, 2021 – Issue 7
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