FermanolideTM

The most bioactive ashwagandha by a unique fermentation process
 
Conversion of the glycolised saponines to the more active form
Withaferin A is degraded by fermentation to a negligible level
The content of withanolide A has been increased by about 70 %
Formation of SOD-like substances or smaller active antioxidant molecules
Much lower daily dose needed

What is Fermanolide™?

Fermanolide™ is fermented ashwagandha, a much-appreciated medicinal herb in Ayurveda. The most valuable part of ashwagandha is the root. This wonderful herb has been made even more powerful than it already is through a patented and innovative Biotransforming Fermentation Technology!

The root of ashwagandha contains many active compounds of which the following are the most important:

  • steroidal lactones  (steroidal saponins) such as withanolides (A-D & Z), withaferin A, withanone, …
  • withanoside series  of steroidal lactones (usually withanoside IV and VI), sominone (active metabolite and aglycon of withanoside IV)
  • withanolide glycosides  (saponins), which are referred to as sitoindosides (or glycowithanolides)
  • alkaloids  as a.o. isopelletierine, anaferine, cuscohygrine, anahygrine, …
  • ashwagandhanolide & withanolide sulfoxide

At present, more than 12 alkaloids, 40 withanolides, and several sitoindosides (a withanolide containing a glucose molecule at carbon 27) have been isolated and reported from aerial parts and roots of Withania species.


Why fermenting ashwagandha?

Biotransformation of secondary plant substances

The most active components of ashwagandha are the withanolides, withanosides and glycowithanolides, all calledsaponins. The focus is mainly on the conversion of the original glycolised saponines to the more active form through our proprietary lactic acid fermentation. Due to their bulky molecular structures, the saponins are poorly membrane permeable and prone to degradation. The mass of the original withanolides, withanosides and glycowithanolides decreases after fermentation due to the removal of the sugar molecules. This process is called deglycosylation. The form is the so called aglycone form, which is permeable and hence directly bioactive. Smaller molecules that are very active and well-studied, penetrate the body more easily!

Withaferin A is degraded by fermentation to a negligible level and therefore there is no risk of cell toxicity.

A specific probiotic strain in the fermentation process is able to break down withaferin A. Its genotoxic potential should be carefully considered for functional foods and dietary supplements. The amount of withaferin A in Fermanolideis less than 0.01%, making it very safe for human consumption.

The flavonoids are broken down into smaller active antioxidant molecules by fermentation

Formation of SOD-like substances that are not destroyed in the digestive tract and perform the same function as superoxide dismutase (SOD)!

The content of withanolide A has been increased by about 70 % after fermentation at a stable level to ensure functional physiological activity.

A study shows that in addition to the strong antioxidant property, withanolide A provides increased neuroprotection by modulation of endogenous glutathione content in hippocampus during exposure to hypobaric hypoxia.

Withanolide A increases glutathione biosynthesis in neuronal cells by upregulating GCLC level through Nrf2 pathway in a corticosterone dependent manner.

The total withanolides content has been increased by 25 %

A targeted lactic acid fermentation process ensures a substantial increase in the total withanolides content.

Much lower daily dose needed

By the high bioavailability & rapid absorption in the small intestine and the fact that the biotransformed molecules are more stable & stay in the body for at least five days, a daily dose of 150 mg is under normal circumstances enough!

Science

Many studies show the therapeutic properties of ashwagandha. It is therefore scientifically very well founded. However, it is important that the saponins are available in their easily absorbable form because this is a condition for the therapeutic power of this promising plant!

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Health benefits

  • It has been shown to reduce stress and anxiety in both animal and human studies
  • May improve brain function, memory, reaction time, and the ability to perform tasks
  • May help lower cortisol levels in chronically stressed individuals.
  • May be beneficial for normalizing thyroid indices in subclinical hypothyroid patients
  • Helps increase testosterone levels and significantly boosts sperm quality and fertility in men
  • It has been shown to lower blood sugar levels in several studies
  • It has been shown to increase natural killer cell activity and decrease markers of inflammation
  • Helps promote muscle strength, size and recovery
  • Helps enhance cardiorespiratory endurance

Legislation

Europe
Ashwagandha is authorized in EU for use in food supplements.

Belgium
Ashwagandha is a plant that appears on the list of permitted plants in Belgium. It is listed in The Royal Decree of 29 August 1997 on the manufacture and trade of foodstuffs composed or containing plants or plant preparations.

Belfrit
Ashwagandha is on the Belfrit list and is allowed in Belgium, France and Italy.

Fermented ashwagandha is obtained by fermentation, a procedure traditionally used in food production, and does not fall under Regulation (EU) no. 2015/2283 on novel foods.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA) and price quotation.

Storage
Due to the hygroscopic nature, please store at dry conditions in an airtight container. Shelf life is minimum two years at 25oC and below 70% RH in original sealed package.

MOQ (minimum order quantity) 20 kg

FormUseDosageStandardized on
PowderNutritional supplements and functional food100-300 mg/dayTotal withanolides > 1,5 % Withanolide A > 800 mcg

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References

  • Archana R, Namasivayan A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999; 64:91-93.
  • Bilal Ahmad Mir, Jabeena Khazir, Nisar A. Mir, Tanvir-ul Hasan and Sushma Koul. Botanical, chemical and pharmacological review of Withania somnifera (Indian ginseng): an ayurvedic medicinal plant. Indian Journal of Drugs and Diseases Vol:1 Issue:6 Sep. 2012 ISSN: 2278- 2958
  • Bone K. Clinical Applications of Ayurvedic and Chinese Herbs. Monographs for the Western Herbal Practitioner. Australia: Phytotherapy Press; 1996:137-141.
  • Chihiro Tohda and Eri Joyashiki. Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET. British Journal of Pharmacology (2009), 157, 1427–1440
  • Dadkar VN, Ranadive NU, Dhar HL. Evaluation of antistress (adaptogen) activity of Withania somnifera (Ashwagandha). Ind J Clin Biochem 1987,2:101-108.
  • Mohammad Hossein Mirjalili, Elisabeth Moyano, Mercedes Bonfill, Rosa M. Cusido and Javier Palazón. Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine. Molecules 2009, 14, 2373-2393; doi:10.3390/molecules14072373
  • Narendra Singh, Mohit Bhalla, Prashanti de Jager and Marilena Gilca. An overview on ashwagandha: a rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. (2011) 8(S):208-213 208
  • Shruti Bhasin, Manali Singh and Dipti Singh. Review on bioactive metabolites of Withania somnifera. (L.) Dunal and its pharmacological significance. Journal of Pharmacognosy and Phytochemistry 2019; 8(3): 3906-3909
  • Singh N, Nath R, Lata A, et al. Withania somnifera (ashwagandha), a rejuvenating herbal drug which enhances survival during stress (an adaptogen). Int J Crude Drug Res 1982; 20:29-35.
  • Tomoharu Kuboyama, Chihiro Tohda, and Katsuko Komatsu. Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases. Pharm. Bull. 37(6) 892–897 (2014) Vol. 37