FermogulanTM | Fermented Jiaogulan

The most promising ingredient for healthy aging!
 
Conversion of the saponins (gypenosides) to their bioactive form
Higher bioavailability of all active substances
Formation of SOD-like substances or smaller active antioxidant molecules
Much lower daily dose needed

What is Fermogulan™?

Fermogulan™ is fermented jiaogulan or Gynostemma pentaphyllum (Thunb.), a climbing perennial vine of the Cucurbitaceae family native to certain parts of South and Southeast Asia. In ancient China, jiaogulan was basically used as an energizing agent and rejuvenating elixir.

This ‘immortality herb’ has been made even more powerful than it already is through a patented and innovative Biotransforming Fermentation Technology!

Fermogulan™ contains polysaccharides, vitamins (carotene), amino acids, flavonoids and Dammarane-type saponins (gypenosides). Circa 25% of the jiaogulan gypenosides are like ginsenosides found in Panax ginseng. Guarantee of Quality: 100% natural, wildgrowing, no pesticide residues, no preservatives, no heavy metal contamination and nonGMO.


Why fermenting jiaogulan?

An innovative functional-oriented and microbial fermentation creates a biotransformation of the secondary metabolites of jiaogulan. During fermentation microbial enzymes transform poorly available herbal components into more easily absorbable healthpromoting metabolites!

What is this transformation all about?

The active components of the jiaogulan plant are essentially gypenosides, also called saponins.

The fermentation of plant extracts is still very new, and the focus is mainly on the conversion of the original glycolised saponines to the more active form. Due to their bulky molecular structures, the gypenosides are poorly membrane permeable and must therefore be further degraded.

The mass of the original gypenosides decreases after fermentation due to the removal of the sugar molecules from the gypenosides. This process is called deglycosylation. The form is the so called aglycone form, which is permeable and hence directly bioactive. Smaller molecules that are very active and well-studied, penetrate the body more easily!

Formation of new components as the rare ginsenosides

Enrichment in Compound K, Rg3 and Rh2

HPLC fingerprint analysis of rare ginsenosides in wild-growing jioagulan before (A) and after (B) fermentation. In comparison with native (unfermented) wildgrowing jiaogulan, fermented wildgrowing jiaogulan contains about:

  • 13-fold more ginsenoside CK (Compound K) ➝ anti-inflammatory effect
  • 3-fold more ginsenoside Rg3 ➝ tumor inhibition
  • 2-fold more ginsenoside Rh2 ➝ neuroprotective

Science

Many studies show the therapeutic properties of jiaogulan. It is therefore scientifically very well founded. However, it is important that the gypenosides are available in their easily absorbable form because this is a condition for the therapeutic power of this promising plant!

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Health benefits

  • Unique adaptogen that counteracts the negative effects of stress
  • One of the most superior antioxidants in the plant world
  • Helping slow down ageing by means of AMPK activation
  • Lowering blood glucose and Hemoglobin A1c (HbA1c) levels by significantly improving the insulin sensitivity of the cells
  • Supporting cardiovascular health by neutralizing the oxidative damage to the arteries and regulating the blood pressure by stimulation of nitric oxide (NO)
  • Modulating the immune system
  • Promoting weight loss by activating AMPK and improving insulin sensivity
  • Having antiviral, antifungal and antibacterial properties and can be used in the prevention of colds and the flu.

Legislation

Europe
Gynostemma pentaphyllum (jiaogulan) is authorized in EU for use in food supplements.

Belgium
Gynostemma pentaphyllum (jiaogulan) is a plant that appears on the list of permitted plants in Belgium. It is listed in The Royal Decree of 29 August 1997 on the manufacture and trade of foodstuffs composed or containing plants or plant preparations.

Belfrit
Gynostemma pentaphyllum (jiaogulan) is on the Belfrit list and is allowed in Belgium, France and Italy.

Fermented jiaogulan is obtained by fermentation, a procedure traditionally used in food production, and does not fall under Regulation (EU) no. 2015/2283 on novel foods.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA), and price quotation.

Storage
Due to the hygroscopic nature, please store at dry conditions in an airtight container. Shelf life is at least two years at 25°C and below 70% RH in original sealed package.

MOQ (minimum order quantity) 20 kg

FormUseDosageStandardized on
PowderNutritional supplements and functional food150 - 250 mg/dayTotal gypenosides > 110.0 mg/g

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References

  • Chul Lee, Jin Woo Lee, Qinghao Jin, Hari Jang, Hyun-Jae Jang, Mun-Chual Rho, Myung Koo Lee, Chong Kil Lee, Mi Kyeong Lee, and Bang Yeon Hwang. Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation. Journal of Natural Products 2015 78 (5), 971-976
  • Dr. Jialiu Liu, Michael Blumert (April 1999). Jiaogulan: China’s “Immortality Herb”–Unlocking the Secrets of Nature’s Powerful Adaptogen and Antioxidant. Torchlight Publishing. ISBN: 978-1-88708-916-6
  • Jiang Enping et al. Protective effects of gypenosides on PC12 cell injury induced by oxidative stress. Human Health and Biomedical Engineering (HHBE), 2011 International Conference on, IEEE, 19-22 Aug. 2011, p.410-413
  • L Li, L Jiao, B H Lau. Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes. Department of Microbiology, School of Medicine, Loma Linda University, CA. Cancer biotherapy 02/1993; 8(3):263-72.
  • Miles A. Tanner, Xin Bu, J.Alan Steimle, Paul R. Myers. The Direct Release of Nitric Oxide by Gypenosides Derived from the Herb Gynostemma pentaphyllum. Nitric Oxide, Volume 3, Issue 5, October 1999, Pages 359-365
  • Samer Megalli, Neal M. Davies, and Basil D. Roufogalis; Anti-Hyperlipidemic and Hypoglycemic Effects of Gynostemma pentaphyllum in the Zucker Fatty Rat; J Pharm Pharmaceut Sci (www.cspscanada.org) 9(3):281-291, 2006
  • Wan Jijin Ge Zhenhua et al.; The Effects of Gynostenmma Pentaphyllum on Proliferation & Immunity of Tumor Cells; Journal of Fujian College of Traditional Chinese Medicine; 1993-03
  • WANG Qiugui; CHENG Yewen et al; Effects of Gynostemma Pentaphyllum on the Contents of SOD, GSH-PX, MDA, LDH and ATPase in Brain, Heart and Kidney of Severely Burned Rats[J]; Journal Of Xianning Medical College;1999-04
  • Yuan Quan, Yijun Yang, Huixing Wang, Bo Shu, Qi-hai Gong, Minzhang Qian. Gypenosides attenuate cholesterol induced DNA damage by inhibiting the production of reactive oxygen species in human umbilical vein endothelial cells. Molecular Medicine Reports. 12/2014; 11(4).
  • Zhang, Guang-Lin et al. Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation. Behavioural Pharmacology: October 2011 – Volume 22 – Issue 7 – p 633–644