Short-chain & medium-chain fatty acids
made available for the gut microbiome and the colonocytes

What is Epithefood™?

EpitheFood™ delivers different short-chain (SCFAs) and mediumchain (MCFAs) fatty acids into the colon.

These fatty acids are offered as mono-, di- and triglycerides. These glycerides of fatty acids are broken down by the enzymes of the microbiome into fatty acids.

The glycerides of EpitheFood™ mostly arrive in the ileum and colon.

What makes Epithefood™ so special?

This mix of fatty acids (C4, C8, C10, C12) provides greater stability. These fatty acids are almost not broken down in the small intestine and enter directly into the colon where they are further converted by various types of lipase.
Epithefood™ is highly effective because of the following reasons:

  • stimulates transcription of the enzym genes, improving in situ SCFA production
  • lowering the acidity of the environment in the intestines
  • optimization of the intestinal flora, better growth of good bacteria and inhibition of pathogenic bacteria
  • contribution to the improvement of intestinal function
  • direct source of energy for certain good bacteria and colonocytes
  • healthy colonocytes that renew better and support the immune system
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Exceptional properties of EpitheFood™

  • An innovative production process brings SCFAs & MCFAs directly into the colon
  • Contains SCFAs & MCFAs stimulating the microbiome to make more SCFA’s
  • Restores the normal function of the immune system in the gut
  • Fights dysbiosis or an unbalanced microbiome

Why are SCFAs & MCFAs so important for the gut?

Preferred energy source
For the mucosal cells of the colon (colonocytes), a continuous source of energy is essential for their maturation and function. Most of the energy is coming from SCFAs produced by the microbiome from fibers. Normally fatty acids in the form of glycerides are emulsified by the bile salts. Then these glycerides are hydrolyzed by the pancreatic lipases and absorbed. In the case of EpitheFood™, the pancreatic lipases which get into the small intestine are not able to transform these glycerides into fatty acids, in order to make them absorbable. Therefore, the lipases of the microbiome must take care of the hydrolysis and making the fatty acids available as an energy source for the colonocytes and the microbiome.

Short-chain fatty acids (SCFAs)
The amount of SCFAs produced and absorbed from the colon content can account for up to 15% of total human energy uptake. Of the produced SCFAs, butyrate is the preferred energy source for colonocytes. Lack of SCFAs in the colon results in energy shortage of the colonocytes and so to mucosal atrophy.

Impact on the immune system
SCFAs are converted into ATP by the cells. When insufficient SCFAs are present, epithelial cells do not have enough energy to renew themselves. But most importantly, inflammation occurs due to environmental stress, lack of energy for renewal, and disruption of the immune system, including excessive formation of cytokines. Cytokines evoke more cytokines and a real storm can occur, making things worse. Some SCFAs directly suppress so-called bad bacteria. Butyric acid affects gram-negative bacteria such as E. Coli and Salmonella. While capric, caprylic an lauric acid put pressure on some gram-positive bacteria like Streptococcus and Clostridium.


  1. 1.
    Many studies show the therapeutic properties of SCFAs & MCFAs. It is therefore scientifically very well founded. SCFAs & MCFAs are essential for gut integrity by regulating the luminal pH, mucus production, providing fuel for epithelial cells and effects on mucosal immune function.
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Health benefits

  1. Energy source for colonocytes and mucosal cells in general
  2. Energy source for beneficial gut flora
  3. Stimulates the production of SCFAs in the colon. Main beneficiary is the epithelium
  4. Helps immune system around the gut to recover
  5. Reduces oxidative stress of the colon and ileum
  6. Lowers the pH of the stools making a better environment for beneficial bacteria
  7. Decreases potentially pathogenic gastrointestinal microorganisms
  8. Strong help to restore a balanced microbiome
  9. Reduction of gastro-intestinal discomfort

Technical data

Common Name
EpitheFood™ - mixture of SCFAs & MCFAs
Fatty acids: C4 | butyric acid 8.5-15.5 % (m/m); C8 | caprylic acid 14.5-21.5 % (m/m); C10 | capric acid 13.0-20.0 % (m/m); C12 | lauric acid 16.5-23 % (m/m)
Powder/ Oil
Nutritional supplements and functional food
Recommended dose
Therapeutic posology: 1.5 – 2.0 g
Preventive posology: 0.5 – 1.0 g
EpitheFood™ is a trademark of Fermedics BV.