Highly bioactive ashwagandha obtained
by traditional lactic acid fermentation

Fermanolide™ is fermented ashwagandha, a highly valued medicinal herb in Ayurveda. The most valuable part of ashwagandha is the root.

This adaptogenic herb has been activated by lactic acid fermentation.

The great benefit of fermentation

  • Better absorption of secondary plant metabolites
    The main focus is on the conversion of the original glycolised saponines such as withanolides to the more active form through our proprietary lactic acid fermentation.
  • The content of withanolide A has been increased by about 70 % after fermentation
  • The total withanolides content has been increased by 25 %
  • The flavonoids are broken down into smaller active antioxidant molecules by fermentation
    The presence of SOD-like substances are not destroyed in the digestive tract as is the case with oral ingestion of superoxide dismutase (SOD). These antioxidants have a similar function to SOD.
  • Withaferin A is degraded by fermentation to a negligible level
    A specific probiotic strain in the fermentation process is able to break down withaferine A. Therefore, eliminating the risk of cell toxicity in case of long-term ingestion. Its genotoxic potential should be carefully considered for functional foods and dietary supplements.
  • Paraprobiotic effect
    Fermanolide™ contains paraprobiotics with similar health-promoting benefits as live probiotic strains.
  • Much lower daily dose needed
    By the high bioavailability and rapid absorption in the small intestine, a daily dose of 150 mg is enough under normal circumstances.

Nature’s intelligence

The advantage of Fermanolide™ is that the natural matrix of the plant has been preserved. Together with the high bioavailability of the active substances, this ingredient is much safer than those who only offer high standardizations on withanolides.

The ashwagandha plant contains many other intelligent substances in addition to the withanolides that are highly beneficial to the body, also in their best absorbable form via traditional fermentation. It is the synergy of secondary plant metabolites in their best absorbable form that plays an important role in the health benefits.

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Withanolides are the major bioactive compounds present in ashwagandha, but not all withanolides are beneficial, especially withaferin A with genotoxic potential. Fermanolide™, fermented ashwagandha, contains almost no withaferin A, making it very safe for human consumption unlike many other non-fermented ashwagandha ingredients. Fermanolide™ contains about 3 times more withanolide A than non-fermented ashwagandha which makes it much more potent and efficient.

Why choose Fermanolide™?

  1. 1.
    Is highly standardized in withanolides (saponins)
  2. 2.
    Conversion of the glycolised saponines to the more active form
  3. 3.
    Withaferin A is degraded by fermentation to a negligible level
  4. 4.
    The content of withanolide A has been increased by about 70 %
  5. 5.
    Formation of SOD-like substances or smaller active antioxidant molecules
  6. 6.
    Much lower daily dose needed
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Health benefits

  1. It has been shown to reduce stress and anxiety in both animal and human studies
  2. May improve brain function, memory, reaction time, and the ability to perform tasks
  3. May help lower cortisol levels in chronically stressed individuals.
  4. May be beneficial for normalizing thyroid indices in subclinical hypothyroid patients
  5. Helps increase testosterone levels and significantly boosts sperm quality and fertility in men
  6. It has been shown to lower blood sugar levels in several studies
  7. It has been shown to increase natural killer cell activity and decrease markers of inflammation
  8. Helps promote muscle strength, size and recovery
  9. Helps enhance cardiorespiratory endurance

Technical data

Common Name
Fermanolide™ - Fermented Ashwagandha
Botanical Origin
Withania somnifera
Plant source
Standardized to contain
> 1,5% total withanolides
> 800 mcg withanolide A
Nutritional supplements and functional food
Recommended dose
100 – 250 mg per day
Fermanolide™ is a trademark of Fermedics BV.