Agaricus blazei mycelium AB12

Highly bioactive beta-glucans
Unique mushroom fermentation through patented technology!

What is Agaricus blazei (subrufescens)?

Agaricus blazei, also called the “almond mushroom” due to its almond taste, is a medicinal and culinary mushroom that is becoming increasingly popular worldwide.

Agaricus blazei is particularly recognized for its cell-regulating and immune stimulating effect. Scientific studies have also shown that this mushroom has anti-inflammatory, anti-allergic properties, as well as hepatoprotective and antiviral activity.  In addition, it is said to lower blood sugar levels and to have a beneficial effect on cholesterol.

Why choosing Agaricus blazei through submerged fermentation?

Submerged cultivation is the best technology to manage the identity and purity of medicinal mushrooms without contamination. The bioactive substances of mushrooms are identified not only in the fruit body, but also in the mycelium culture and broth.

The most powerful ß -glucans are found in the mycelium, because the defence of the mushroom is most needed in the substrate. They are the so-called branched ß- 1,3-1,6 glucans.

After long and complex research, it has been possible to make liquid substrates for the different mushrooms where the mycelium can develop under ideal conditions. A sterile and liquid substrate is used where the mycelium is introduced and further develops for several weeks. When the mycelium is fully developed, everything is filtered. The filtration removes the not converted liquid substrate, but also the less active ß -glucans. Low-temperature membrane filtration with a molecular weight cut-off (MWCO) of 5,000 Da produces high-molecular ß-glucans that are highly bioactive. The filtrate containing the excreted beta-glucans, but also the mycelium is then freeze-dried.

This expensive technique guarantees optimal preservation of the triple helix structure of the ß -glucans, i.e. a biological activity that is not affected. The triple helix structure in most mushroom powders is largely damaged by heating and extraction using solvents.

Triple helix structure

Because we use a sterile substrate that allows the mycelium to develop in a sterile environment, the final product is also not bacterially contaminated. So extremely safe!

Agaricus blazei mycelium AB12 shows a clear genetic similarity to fruiting bodies that grow naturally.

Genetic similarities reach:

Fermedics’ mushroom powders belong to the top of the world due to the advanced & unique production process in which a high concentration of active substances with an enormous stability and high efficiency is achieved.

Distinctive features

Unique properties of the production process

  • Produced by patented submerged fermentation
  • Subjected to low temperature membrane filtration technology
  • Reliable strain identification by DNA Sequence alignment (ITS1, 5.8 DNA, ITS2)
  • Very similar to wild type (WT) strain
  • Assessment of long-term storage
  • Active ingredient analyses and full safety assessment
  • High content of secondary metabolites and bioactive compounds
  • Bio-sustainability & environmentally friendly
  • Free of contaminants such as pesticides and heavy metals


What makes Agaricus blazei mycelium AB12 so special?

  • Contains the most effective beta-glucans because of the:
    • preservation of the triple helix structure
    • very high absorbability due to water solubility
    • presence of high molecular weight extracellular beta-glucans
    • Specific branching (β-1,3 – β-1,6 glucans) which are more biologically active
  • Strong similarity to the wild variety through reliable strain identification
  • 100% pure polysaccharides and beta-glucans derived from the mycelium and extracellular excretion in the fermentation fluid
  • No risk of contamination (microbiological as well as chemical)
  • 100 % pure powder
    • no heavy metal contamination
    • no pesticides/fungicides
    • no chemical additives
    • no extraction with solvents destroying triple helix structure
  • No functional starch derivatives, cyclodextrin, modified starches or other thickeners as additives
  • No traces of starch or cereals from the culture matrix or substrate.
  • No subsequent addition of polysaccharides.
More information

Health benefits

  • Anti-inflammatory properties
  • Helps to relieve allergy
  • Liver protective
  • Supporting the immune system
  • Regulating blood sugar level


Agaricus blazei is authorized in EU for use in food supplements.

Agaricus blazei is permitted in Belgium. This mushroom is listed in The Royal Decree of 29 August 1997 on the manufacture and trade of foodstuffs composed or containing plants or plant preparations.

Agaricus blazei is on the Belfrit list and is allowed in Belgium, France and Italy.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA), and price quotation.

Due to the hygroscopic nature, please store at dry conditions in an airtight container. Shelf life is at least two years at 25°C and below 70% RH in original sealed package.

MOQ (minimum order quantity) 20 kg

FormUseDosageActive compounds
PowderNutritional supplements
Functional food
0,5 – 1,0 g/dayPolysaccharides

Would you like to receive more scientific info about Agaricus blazei mycelium?

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  • Firenzuoli F., Gori L., Lombardo G. 2008. The medicinal mushroom Agaricus blazei Murrill: Review of literature and pharmaco-toxicological problems. Evidence-Based Complementary and Alternative Medicine, 5, 1: 3–15.
  • Ji, W., Huang, H., Chao, J., Lu, W., and Guo, J. (2014). Protective effect of Agaricus brasiliensis on STZ-induced diabetic neuropathic pain in rats. Evidence-based comple mentary and alternative medicine: eCAM 2014, 679259.
  • Jiang, L., Yu, Z., Lin, Y., Cui, L., Yao, S., Lv, L., and Liu, J. (2018). Low-molecular-weight polysaccharides from Agaricus blazei Murrill modulate the Th1 response in cancer immunity. Oncol Lett 15, 3429-3436.
  • Liu, J., and Sun, Y. (2011). Structural analysis of an alkali-extractable and water-soluble polysaccharide (ABP-AW1) from the fruiting bodies of Agaricus blazei Murill. Car bohydrate polymers 86, 429-432.
  • Wang H., Fu Z., Han C. 2013. The medicinal values of culinary-medicinal royal sun mushroom (Agaricus blazei Murrill). Evidence-Based Complementary and Alternative Medicine, 2013, 842619,
  • Cardozo, F.T., Camelini, C.M., Mascarello, A., Rossi, M.J., Nunes, R.J., Barardi, C.R., de Mendonca, M.M., and Simoes, C.M. (2011). Antiherpetic activity of a sulfated poly saccharide from Agaricus brasiliensis mycelia. Antiviral Res 92, 108-114.