Cordyceps sinensis mycelium CS12

Highly bioactive beta-glucans
 
Unique mushroom fermentation through patented technology!

What is cordyceps sinensis?

Cordyceps sinensis is a unique fungus that particularly parasitizes the larvae of moths and converts them into sclerotia from which the fungus fruiting body grows. This medicinal mushroom species is highly valued for its remarkable therapeutic properties and occurs naturally in certain high mountain regions of Asia.  A few scientists have developed techniques to cultivate Cordyceps with a potential similar to that of the wild species, making the mushroom more affordable and accessible.

Cordyceps sinensis has been used as a medicine in China for over 300 years. This mushroom has always been considered the tonic for “all diseases” because it would improve energy, appetite, stamina, libido, and is also used in the treatment of several diseases such as immune weakness, cardiovascular and respiratory diseases. That is why the mushroom is considered “anti-aging”.

There are several types of Cordyceps, but Cordyceps sinensis is most commonly used. The main active substances in Cordyceps sinensis are bioactive polysaccharides and cordycepin.

In addition, it also contains other beneficial substances such as adenosine and amino acids that are required for the production of ATP. That is why this mushroom is mainly used for general fatigue and low energy levels. Numerous scientific studies show that Cordyceps sinensis polysaccharides (CSP) or cordycepin have various physiological and health effects, including rapid relief from fatigue, anti-inflammatory & antihypertensive properties, kidney protection, immune support and cell protection against PM2.5 or acute lung damage.


Why choosing cordyceps sinensis through submerged fermentation?

Submerged cultivation is the best technology to manage the identity and purity of medicinal mushrooms without contamination. The bioactive substances of mushrooms are identified not only in the fruit body, but also in the mycelium culture and broth.

The most powerful ß -glucans are found in the mycelium, because the defence of the mushroom is most needed in the substrate. They are the so-called branched ß- 1,3-1,6 glucans.

After long and complex research, it has been possible to make liquid substrates for the different mushrooms where the mycelium can develop under ideal conditions. A sterile and liquid substrate is used where the mycelium is introduced and further develops for several weeks. When the mycelium is fully developed, everything is filtered. The filtration removes the not converted liquid substrate, but also the less active ß -glucans. Low-temperature membrane filtration with a molecular weight cut-off (MWCO) of 5,000 Da produces high-molecular ß-glucans that are highly bioactive. The filtrate containing the excreted beta-glucans, but also the mycelium is then freeze-dried.

This (expensive) technique guarantees optimal preservation of the triple helix structure of the ß -glucans, i.e. a biological activity that is not affected. The triple helix structure in most mushroom powders is largely damaged by heating and extraction using solvents.

Triple helix structure

Because we use a sterile substrate that allows the mycelium to develop in a sterile environment, the final product is also not bacterially contaminated. So extremely safe!

The use of submerged fermentation also ensures that a relatively high amount of N6(2)-hydroxyethyl-adenosine (N6-HEA) is formed and this is unique.

Cordyceps sinensis mycelium CS12 shows a clear genetic similarity to fruiting bodies that grow naturally.

Image
Genetic similarities reach:
99.85%

Fermedics’ mushroom powders belong to the top of the world due to the advanced & unique production process in which a high concentration of active substances with an enormous stability and high efficiency is achieved.

Distinctive features

Unique properties of the production process

  • Produced by patented submerged fermentation
  • Subjected to low temperature membrane filtration technology
  • Reliable strain identification by DNA Sequence alignment (ITS1, 5.8 DNA, ITS2)
  • Very similar to wild type (WT) strain
  • Assessment of long-term storage
  • Active ingredient analyses and full safety assessment
  • High content of secondary metabolites and bioactive compounds
  • Bio-sustainability & environmentally friendly
  • Free of contaminants such as pesticides and heavy metals

 

What makes Cordyceps sinensis mycelium CS12 so special?

  • Contains the most effective beta-glucans because of the:
    • preservation of the triple helix structure
    • very high absorbability due to water solubility
    • presence of high molecular weight extracellular beta-glucans
    • Specific branching (β-1,3 – β-1,6 glucans) which are more biologically active
  • Strong similarity to the wild variety through reliable strain identification
  • 100% pure polysaccharides and beta-glucans derived from the mycelium and extracellular excretion in the fermentation fluid
  • No risk of contamination (microbiological as well as chemical)
  • Relatively high amount of N6(2)-hydroxyethyl-adenosine (N6-HEA) due to submerged fermentation
  • 100 % pure powder
    • no heavy metal contamination
    • no pesticides/fungicides
    • no chemical additives
    • no extraction with solvents destroying triple helix structure
  • No functional starch derivatives, cyclodextrin, modified starches or other thickeners as additives
  • No traces of starch or cereals from the culture matrix or substrate.
  • No subsequent addition of polysaccharides.
More information

Health benefits

  • Anti-fatigue
  • Anti-inflammatory properties
  • Boosting physical strength
  • Immune system support
  • Improving respiratory function
  • Regulating blood pressure
  • Relieving common cold
  • Helps to support the kidneys

Legislation

Europe
Cordyceps sinensis is authorized in EU for use in food supplements.

Belgium
Cordyceps sinensis is permitted in Belgium. This mushroom is listed in The Royal Decree of 29 August 1997 on the manufacture and trade of foodstuffs composed or containing plants or plant preparations.

Belfrit
Cordyceps sinensis is on the Belfrit list and is allowed in Belgium, France and Italy.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA), and price quotation.

Storage

Due to the hygroscopic nature, please store at dry conditions in an airtight container. Shelf life is at least two years at 25°C and below 70% RH in original sealed package.

MOQ (minimum order quantity) 20 kg

FormUseDosageActive compounds
PowderNutritional supplements
Functional food
0,5 – 1,0 g/dayPolysaccharides > 12 %
β- glucans > 5 %
Cordycepin > 10 μg/g
N6-2-hydroxyethyl adenosine(N6-HEA) > 50 μg/g

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References

  • Holliday J., Cleaver M. 2008. Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review. International Journal of Medicinal Mushrooms, 10, 3: 219– 234.
  • Kumar, R., Negi, P., Singh, B., Ilavazhagan, G., Bhargava, K., and Sethy, N.K. (2011). Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators. Journal of ethnopharmacology 136, 260-266.
  • Lei, J., Wei, Y., Song, P., Li, Y., Zhang, T., Feng, Q., and Xu, G. (2018). Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress. European Journal of pharmacology 818, 110-114.
  • Lin B.Q., Li S.P. 2011. Cordyceps as an herbal drug. In: Herbal medicine: Biomolecular and clinical aspects. 2nd edition. Benzie I.F.F., Wachtel-Galor S. (editors). Boca Raton, FL, CRC Press: 73–105.
  • NB Research Center. (2018). The functional study of Cordyceps sinensis and its application for promoting health.
  • Panda A.K., Swain K.C. 2011. Traditional uses and medicinal potential of Cordyceps sinensis of Sikkim. Journal of Ayurveda and Integrative Medicine, 2, 1: 9–13.
  • Xiang, F., Lin, L., Hu, M., and Qi, X. (2016). Therapeutic efficacy of a polysaccharide isolated from Cordyceps sinensis on hypertensive rats. International journal of biological macromolecules 82, 308-314.