Hericium erinaceus mycelium HE12

Highly bioactive beta-glucans
Unique mushroom fermentation through patented technology!

What is Hericium erinaceus or Lion’s mane?

Hericium erinaceus, also known as ‘Lion’s Mane’, is a medicinal mushroom that has long been recognized in traditional Chinese medicine for a variety of therapeutic properties. Scientific research shows especially the beneficial effects on the nervous system. It has neuroprotective properties, helps prevent dementia and neurodegenerative diseases, improve brain function and relieve depression and anxiety.  In addition, it has a beneficial effect on the heart and immune system, blood sugar levels and has antioxidant properties.

Scientists have identified many different biologically active compounds in Hericium erinaceus. These include pharmacologically important β-glucan polysaccharides, phenols with antioxidant properties, and ergosterol. This active substance is converted into vitamin D2 in the presence of sunlight or ultraviolet light. The main group of active substances in addition to the active polysaccharides are the erinacines, compounds in Hericium erinaceus that show neuroprotective properties. These and related compounds stimulate the synthesis of nerve growth factor involved in maintaining and organizing the function of neurons, thus helping to prevent neurodegenerative diseases.


Why choosing Hericium erinaceus (Lion’s mane) through submerged fermentation?

Submerged cultivation is the best technology to manage the identity and purity of medicinal mushrooms without contamination. The bioactive substances of mushrooms are identified not only in the fruit body, but also in the mycelium culture and broth.

The most powerful ß -glucans are found in the mycelium, because the defence of the mushroom is most needed in the substrate. They are the so-called branched ß- 1,3-1,6 glucans.

After long and complex research, it has been possible to make liquid substrates for the different mushrooms where the mycelium can develop under ideal conditions. A sterile and liquid substrate is used where the mycelium is introduced and further develops for several weeks. When the mycelium is fully developed, everything is filtered. The filtration removes the not converted liquid substrate, but also the less active ß -glucans. Low-temperature membrane filtration with a molecular weight cut-off (MWCO) of 5,000 Da produces high-molecular ß-glucans that are highly bioactive. The filtrate containing the excreted beta-glucans, but also the mycelium is then freeze-dried.

This (expensive) technique guarantees optimal preservation of the triple helix structure of the ß -glucans, i.e. a biological activity that is not affected. The triple helix structure in most mushroom powders is largely damaged by heating and extraction using solvents.

Triple helix structure

Because we use a sterile substrate that allows the mycelium to develop in a sterile environment, the final product is also not bacterially contaminated. So extremely safe!

An additional advantage of submerged fermentation is the increased production of Erinacine A, which naturally occurs only in the mycelium.

Hericium erinaceus mycelium HE12 shows a clear genetic similarity to fruiting bodies that grow naturally.

Genetic similarities reach:

Fermedics’ mushroom powders belong to the top of the world due to the advanced & unique production process in which a high concentration of active substances with an enormous stability and high efficiency is achieved.

Distinctive features

Unique properties of the production process

  • Produced by patented submerged fermentation
  • Subjected to low temperature membrane filtration technology
  • Reliable strain identification by DNA Sequence alignment (ITS1, 5.8 DNA, ITS2)
  • Very similar to wild type (WT) strain
  • Assessment of long-term storage
  • Active ingredient analyses and full safety assessment
  • High content of secondary metabolites and bioactive compounds
  • Bio-sustainability & environmentally friendly
  • Free of contaminants such as pesticides and heavy metals


What makes Hericium erinaceus mycelium HE12 so special?

  • Contains the most effective beta-glucans because of the:
    • preservation of the triple helix structure
    • very high absorbability due to water solubility
    • presence of high molecular weight extracellular beta-glucans
    • Specific branching (β-1,3 – β-1,6 glucans) which are more biologically active
  • Strong similarity to the wild variety through reliable strain identification
  • 100% pure polysaccharides and beta-glucans derived from the mycelium and extracellular excretion in the fermentation fluid
  • No risk of contamination (microbiological as well as chemical)
  • Relatively high amount of Erinacine A due to submerged fermentation
  • 100 % pure powder
    • no heavy metal contamination
    • no pesticides/fungicides
    • no chemical additives
    • no extraction with solvents destroying triple helix structure
  • No functional starch derivatives, cyclodextrin, modified starches or other thickeners as additives
  • No traces of starch or cereals from the culture matrix or substrate.
  • No subsequent addition of polysaccharides.
More information

Health benefits

  • Antioxidative properties
  • Immune support
  • Improving memory, focus & concentration
  • Neuroprotective properties
  • Relieving depression and anxiety


Hericium erinaceus is authorized in EU for use in food supplements.

Hericium erinaceus is permitted in Belgium. This mushroom is listed in The Royal Decree of 29 August 1997 on the manufacture and trade of foodstuffs composed or containing plants or plant preparations.

Hericium erinaceus is on the Belfrit list and is allowed in Belgium, France and Italy.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA), and price quotation.

Due to the hygroscopic nature, please store at dry conditions in an airtight container. Shelf life is at least two years at 25°C and below 70% RH in original sealed package.

MOQ (minimum order quantity) 20 kg

FormUseDosageActive compounds
PowderNutritional supplements
Functional food
0,5 – 1,0 g/dayPolysaccharides
Erinacine A

Would you like to receive more scientific info about Hericium erinaceus mycelium?

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  • Brandalise, F., Cesaroni, V., Gregori, A., Repetti, M., Romano, C., Orru, G., Botta, L., Girometta, C., Guglielminetti, M.L., Savino, E., and Rossi, P. (2017). Dietary supplementation of Hericium erinaceus increases mossy fiber-CA3 hippocampal neurotransmission and recognition memory in wild-type mice. Evidence-based complementary and alternative medicine: eCAM 2017, 3864340.
  • Chen, T.-C., Huang, C.-C., and Chin, T.-Y. (2018). The effect of Hericium erinaceus mycelium and Erinacine A in the rat model of hemiparkinsonism. NB reaseach center.
  • Friedman M. 2015. Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (lion’s mane) mushroom fruiting bodies and mycelia and their bioactive compounds. Journal of Agricultural and Food Chemistry, 63, 32: 7108-7123.
  • Khan M.A., Tania M., Liu R., Rahman M.M. 2013. Hericium erinaceus: An edible mushroom with medicinal values. Journal of Complementary and Integrative Medicine, 10, 1: 253–258.
  • Ma B.J., Shen J.W., Yu H.Y., Ruan Y., Wu T.T., Zhao X. 2010. Hericenones and erinacines: Stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. Mycology, 1, 2: 92–98.
  • Tsai, Y.-C., Lin, Y.-C., Huang, C.-C., Villaflores, O.B., Wu, T.-Y., Huang, S.-M., and Chin, T.-Y. (2018). Hericium erinaceus mycelium and its isolated compound, Erinacine A, ameliorate high-fat high-sucrose diet-induced metabolic dysfunction and spatial learning deficits in aging mice. (in submission).
  • Wang, X.Y., Yin, J.Y., Zhao, M.M., Liu, S.Y., Nie, S.P., and Xie, M.Y. (2018). Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities. Carbohydrate polymers 186, 100-109.
  • Wong K.H., Naidu M., David R.P., Bakar R., Sabaratnam V. 2012. Neuroregenerative potential of lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review). International Journal of Medicinal Mushrooms, 14, 5: 427–446.