GabarelaxTM | GABA obtained by fermentation

Produced by a bio-fermentation technology
 
Improving sleep & mental focus, anti-stress and relieving fatigue
Produced by a bio-fermentation technology, using Lactobacillus hilgardii
More than 98 % pure & bio-identical GABA
Clinically studied

What is Gabarelax™?

Gabarelax™ is a naturally sourced bio-identical GABA, produced by a bio-fermentation technology, using Lactobacillus hilgardii!!

The fermentation process of Gabarelax™ uses the same kind of bacteria that is used to ferment vegetables, cheese, and other traditional foods.

Gabarelax™ is the 100 % natural form of GABA and managed according to ISO9001, HACCP, ISO22000 and GMP quality management systems ➝ safety, stability and reliability guaranteed!

Kosher and Halal certified – vegan – non-GMO.

 

 

 

 

 

 

 


What is GABA?

Gamma aminobutyric acid (GABA) is a natural active non-protein amino acid.

  • GABA exists widely in nature, including the mammalian nervous system, botanicals such as tomatoes, grapes, potatoes, pumpkin, and tea, as well as fermented foods such as kimchi, germinated brown rice and pickles, which are also rich in GABA.
  • GABA plays a fundamental role in the regulation of the life activities of the organism.
  • GABA is an important neurotransmitter widely distributed throughout the central nervous system. It serves as a critical calming agent for the body, helping to combat stress and anxiety.
  • Having enough GABA in our body is a guarantee of feeling relaxed and happy. Lack of GABA will lead to tense feelings, fear and sleep problems.

Even though GABA can’t cross the blood-brain barrier (BBB), it can still affect your brain. The enteric nervous system (ENS) is the network of neurons that controls your gastrointestinal system. The ENS not only contains many GABA receptors but also GABA itself and is connected to the brain via the vagus nerve. Therefore, oral GABA can even affect the brain without passing the BBB through its interaction with the ENS.

Science

Certain studies show the health benefits of GABA for improving the focus, relaxing the body, relieving fatigue and improving sleep. It is therefore scientifically very well founded. A study with Gabarelax™ shows that it has a beneficial effect on stress and sleep disorders.

A few studies with GABA

 

Relax and anti-stress

 

GABA is the most important inhibitory neurotransmitter in the brain, which helps prevent nerve cells from firing too often. Over-firing can cause restless, irritability and anxiety. As such, GABA has a calming and soothing effect.

 

Improving mental focus

GABA can promote mental focus with feelings of calmness. GABA can also increase glucose phosphatase activity, dilate blood vessels to increase blood flow and reduce blood ammonia, so that vigorous activity of the brain cells can promote the metabolism of the brain tissue, restore function of brain cells, improve brain activity, and enhance memory.

 

Relieving fatigue

 

GABA plays an important role in brain functions. It not only regulates cardiovascular and pituitary functions but also modulates renal function. Several studies have reported the effects of GABA on relaxation and fatigue reduction.

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Health benefits

  • Anti-stress
  • Relieving fatigue
  • Improving sleep
  • Improving mental focus
  • Body building & relaxation after exercise
  • Reducing blood pressure
  • Preventing skin ageing

Legislation

Europe
GABA is authorized in EU for use in food supplements.

Belgium
GABA is a nutrient that that has been approved for use in food supplements.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA), and price quotation.

Storage
Due to the hygroscopic nature, please store at dry conditions in an airtight container. Shelf life is at least two years at 25°C and below 70% RH in original sealed package.

MOQ (minimum order quantity) 20 kg

FormDosageUse
Powder200 - 300 mg/dayNutritional supplements and functional food

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References

  • Nemeroff CB. The role of GABA in the pathophysiology and treatment of anxiety disorders. Psychopharmacol Bull 2003; 37:133-146.
  • Kendell SF, Krystal JH, Sanacora G. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opin Ther Targets 2005; 9:153-168.
  • Kugaya A, Sanacora G. Beyond monoamines: glutamatergic function in mood disorders. CNS Spectr 2005; 10:808-819.
  • Gottesmann C. GABA mechanisms and sleep. Neuroscience 2002; 111:231-239.
  • Spila B, Szumillo A. Gabapentin (GBP) in panic disorders – case report. Psychiatr Pol 2006; 40:1061- 1068.
  • Streeter CC, Jensen JE, Perlmutter RM, et al. Yoga asana sessions increase brain GABA levels: a pilot study. J Altern Complement Med 2007; 13:419-426.
  • Khom S, Baburin I, Timin E, et al. Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity. Neuropharmacology 2007; 53:178-187.
  • Unpublished data provided by Pharma Foods International LTD., Kyoto, Japan.
  • Abdou AM, Higashiguchi S, Horie K, et al. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors 2006; 26:201-208.
  • Shiah IS, Yatham LN. GABA function in mood disorders: an update and critical review. Life Sci 1998; 63:1289-1303.
  • Brambilla P, Perez J, Barale F, et al. GABAergic dysfunction in mood disorders. Mol Psychiatry 2003; 8:715,721-737.