Bifidobacterium lactis BLA281

High-tech manufacturing process
 

What is Bifidobacterium lactis?

Bifidobacterium Lactis is a very powerful temporary probiotic bacterium. Although many probiotic strains exist, Bifidobacterium lactis is one of the most versatile and hard-working strains for the human body.  B. Lactis occurs in large numbers in the small and large intestine. In general, their task is to break down body waste and help in the absorption of various vitamins and minerals.

This probiotic helps in the digestion of lactose (fights lactose intolerance) and is an integral part of supporting the overall digestion of sugars, fibres and macronutrients.

Scientific studies have shown that B. lactis optimizes digestion in general, has a relieving effect on ulcerative colitis and can even combat celiac disease. It also helps reduce antibiotic-related diarrhoea and can therefore be a great help in case antibiotic ingestion is necessary.

In addition, B. lactis modulates the immune system and keeps cholesterol levels in balance.

B. Lactis is present in raw milk and is used as a starter culture for cheese, curd cheese and buttermilk.

 

More information

Why choose Bifidobacterium lactis BLA281?

Fermedics’ probiotics are manufactured to the highest standard and based on years of scientific research. Our patented probiotic strains are different from the others since all our probiotics are protected by a patented five-layer microencapsulation technology!

This 5-layer protection also has the following advantages:

  • major logistical advantages
  • probiotic strains also remain more stable in the capsule or sachet
  • no contamination / interaction with the filling system
  • a fluid powder that is easy to encapsulate

In general, only a few % of the probiotics sold can reach the intestines and this is very little. Most of them are dead before they’re consumed and the probiotics that are still alive, are eliminated by more than 60% through the intestinal juices.

 

Tests with probiotics subjected to 5-layer microencapsulation

The 5-layer protection significantly increases the stability and survival of probiotics and has many advantages compared to unprotected probiotics.

The tests clearly show that coated probiotics are resistant to stomach acid, bile salts and other digestive juices, allowing them to reach the intestine intact, which is not the case with unprotected probiotics. Improving the stability and protection against digestive juices of protected probiotics also means that a lower dosage per day is necessary (cost savings) because of the good protection (6 to10 billion bacteria is a good daily dosage).

Stability test shows that coated probiotics remain almost intact (loss of 7 to 8%) after the first 6 months of storage at room temperature, while uncoated probiotics lose nearly 80% of their activity, which is remarkable. Stability test at room temperature for 12 months shows that coated lactic acid bacteria (through patented 5-layer microencapsulation) are much more robust and stable than uncoated bacteria that have already lost much of their activity after 3 months, and after 6 months there is almost no activity, which is absolutely not the case with coated bacteria.

 

Improving storage stability of probiotics

Both uncoated and coated (by patented 5-layer microencapsulation) lactic acid bacteria were stored at 40 °C for four weeks. The result shows that the efficiency of lactic acid bacteria subjected to patented 5-layer microencapsulation is much better (more than 9 log).

 

Properties of Fermedics’ probiotics

More information

Health benefits

  • Lowering lactose intolerance
  • Reduction of intestinal permeability
  • Improving cholesterol levels
  • Improving the entire gastrointestinal function
  • Inhibiting H. pylori
  • Modulating the immune system
  • Protecting intestinal mucosa from gluten damage
  • Reducing colds and flu
  • Relieving ulcerative colitis and celiac disease

Storage condition

  • Transport is in refrigerated conditions. Therefore, it is preferable that the manufacturer of finished products keeps the raw material in refrigerated state until the beginning of production.
  • Frozen probiotics can easily be stored as a raw material for 2 years without having a significant effect on CFU/g. If probiotics are stored in the refrigerator at 4°C – 8°C, the storage time is also substantially better than at room temperature.
  • After production, probiotics in the package should also preferably be stored in the refrigerator between 4°C – 8 °C, as the result is always better for CFU/g.
  • As soon as the finished products leave the company for distribution to wholesalers and retailers, probiotics can be stored at room temperature (+/- 12 months) if the 25°C is not exceeded. This guarantees the consumer a quality product, even if stored at room temperature.
  • Expiry date: 18 months if the preservation conditions are applied as above.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA) and price quotation.

MOQ (minimum order quantity) 10 kg

Legislation

Bifidobacterium lactis belongs to the list of micro-organisms that have obtained Qualified Presumption of Safety (QPS) status, defined by EFSA in Europe (2007) because of their safe use in food (1).

(1) Annex II of Regulation (EU) No 1169/2011

SourceIncubation methodIdentification of microbePotencyFormRecommended daily dosage
fermented soybean milkdeep-layer liquid state incubation16S rDNA gene sequencing1.0 x 1011 CFU/gpowder6.0 x 109

This probiotic is obtained by a fermentation process, freeze-dried and subjected to a patented five-layer microencapsulation technology to protect and preserve each individual probiotic strain optimally. It is a <strong>white to cream-coloured, free-flowing powder</strong> with high stability.

Would you like to receive more scientific info about our probiotics?

Yes please

References

  • Ahmed et al. Impact of consumption of different levels of Bifidobacterium lactis HN019 on the intestinal microflora of elderly human subjects. J Nutr Health Aging. 2007 Jan-Feb;11(1):26-31.
  • Chiang et al. Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses. Eur J Clin Nutr. 2000 Nov;54(11):849-55.
  • Corrêa et al. A randomized formula-controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhoea in infants. J Clin Gastroenterol. 2005 May-Jun;39(5):385-9.
  • Gill et al. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr. 2001 Dec;74(6):833-9.
  • Klein et al. Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr. 2008 May;62(5):584-93.
  • K Lindfors, T Blomqvist, K Juuti-Uusitalo, et al. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol. 2008 Jun; 152(3): 552-558.
  • Lomax AR, Calder PC. Probiotics, immune function, infection and inflammation: a review of the evidence from studies conducted in humans. Curr Pharm Des. 2009;15(13):1428-518.
  • Matsumoto M, Benno Y. Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healthy adult subjects. Mutat Res. 2004 Dec 21;568(2):147-53.
  • Mikkel Jungersen, Anette Wind, Eric Johansen, et al. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12. Microorganisms 2014, 2, 92-110
  • Mohan et al. Effects of Bifidobacterium lactis Bb12 supplementation on intestinal microbiota of preterm infants: a double-blind, placebo controlled, randomized study. J Clin Microbiol. 2006 Nov;44(11):4025-31.