Lactobacillus rhamnosus LCR103

High-tech manufacturing process
 

What is Lactobacillus rhamnosus?

Lactobacillus rhamnosus is a tough bacterium and is resistant to gastric acid and other digestive juices. This strain is part of our microbiome which basically consists of the microbial genes present in our system. Good and bad bacteria live here, but it is the useful species that controls the harmful variety.

L. Rhamnosus, as a strain perhaps a little less known than others of the Lactobacillus species, has some very remarkable health properties.

Studies indicate that supplementation with L. Rhamnosus can reduce feelings of anxiety and relieve symptoms of depression. The combination of this probiotic with prebiotics also has important health benefits for mood.

Another study shows that taking L. Rhamnosus can reduce weight gain and improve diabetes. Much research has also been done with this probiotic that indicates it has a beneficial effect on the treatment of gastrointestinal complaints such as irritable bowel syndrome.

L. Rhamnosus may as well improve general immune function, and a promising study suggests that this strain may be as useful as an antibiotic for the treatment of urinary tract infections.

 

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Why choosing Lactobacillus plantarum LP109?

Fermedics’ probiotics are manufactured to the highest standard and based on years of scientific research. Our patented probiotic strains are different from the others since all our probiotics are protected by a patented five-layer microencapsulation technology!

This 5-layer protection also has the following advantages:

  • major logistical advantages
  • probiotic strains also remain more stable in the capsule or sachet
  • no contamination / interaction with the filling system
  • a fluid powder that is easy to encapsulate

In general, only a few % of the probiotics sold can reach the intestines and this is very little. Most of them are dead before they’re consumed and the probiotics that are still alive, are eliminated by more than 60% through the intestinal juices.

 

Tests with probiotics subjected to 5-layer microencapsulation

The 5-layer protection significantly increases the stability and survival of probiotics and has many advantages compared to unprotected probiotics.

The tests clearly show that coated probiotics are resistant to stomach acid, bile salts and other digestive juices, allowing them to reach the intestine intact, which is not the case with unprotected probiotics. Improving the stability and protection against digestive juices of protected probiotics also means that a lower dosage per day is necessary (cost savings) because of the good protection (6 to10 billion bacteria is a good daily dosage).

Stability test shows that coated probiotics remain almost intact (loss of 7 to 8%) after the first 6 months of storage at room temperature, while uncoated probiotics lose nearly 80% of their activity, which is remarkable. Stability test at room temperature for 12 months shows that coated lactic acid bacteria (through patented 5-layer microencapsulation) are much more robust and stable than uncoated bacteria that have already lost much of their activity after 3 months, and after 6 months there is almost no activity, which is absolutely not the case with coated bacteria.

 

Improving storage stability of probiotics

Both uncoated and coated (by patented 5-layer microencapsulation) lactic acid bacteria were stored at 40 °C for four weeks. The result shows that the efficiency of lactic acid bacteria subjected to patented 5-layer microencapsulation is much better (more than 9 log).

 

Properties of Fermedics’ probiotics

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Health benefits

  • Boosting immunity
  • Prevention of allergy
  • Improving gastrointestinal function
  • Improving lactose intolerance
  • Preventing urinary tract infections
  • Promoting Bifidobacterium growth
  • Reducing IBS symptoms
  • Regulating blood sugar level
  • Regulating emotional behaviour

Storage condition

  • Transport is in refrigerated conditions. Therefore, it is preferable that the manufacturer of finished products keeps the raw material in refrigerated state until the beginning of production.
  • Frozen probiotics can easily be stored as a raw material for 2 years without having a significant effect on CFU/g. If probiotics are stored in the refrigerator at 4°C – 8°C, the storage time is also substantially better than at room temperature.
  • After production, probiotics in the package should also preferably be stored in the refrigerator between 4°C – 8 °C, as the result is always better for CFU/g.
  • As soon as the finished products leave the company for distribution to wholesalers and retailers, probiotics can be stored at room temperature (+/- 12 months) if the 25°C is not exceeded. This guarantees the consumer a quality product, even if stored at room temperature.
  • Expiry date: 18 months if the preservation conditions are applied as above.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA) and price quotation.

MOQ (minimum order quantity) 10 kg

Legislation

Lactobacillus rhamnosus belongs to the list of micro-organisms that have obtained Qualified Presumption of Safety (QPS) status, defined by EFSA in Europe (2007) because of their safe use in food (1).

(1) Annex II of Regulation (EU) No 1169/2011

SourceIncubation methodIdentification of microbePotencyFormRecommended daily dosage
fermented soybean milkdeep-layer liquid state incubation16S rDNA gene sequencing1.0 x 1011 CFU/gpowder6.0 x 109

This probiotic is obtained by a fermentation process, freeze-dried and subjected to a patented five-layer microencapsulation technology to protect and preserve each individual probiotic strain optimally. It is a white to cream-coloured, free-flowing powder with high stability.

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References

  • Beerepoot, M. A. et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Archives of Internal Medicine. 172 (9).
  • Bravo, J. et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences of the United States of America. 108 (38).
  • P. L. Conway, S. L. Gorbach, B. R. Goldin. Survival of Lactic Acid Bacteria in the Human Stomach and Adhesion to Intestinal Cells. Journal of Dairy Science. Volume 70, Issue 1, Pages 1-12. DOI: 10.3168/jds.S0022-0302(87)79974-3.
  • Schmidt, K. et al. Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology. 232 (10).
  • Yadav, H. et al. Beneficial metabolic effects of a probiotic via butyrate induced GLP-1 secretion. The Journal of Biological Chemistry.
  • Zajac, A. et al. A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis. International Forum of Allergy and Rhinology. 5 (6).