More informationLactobacillus salivarius LS159

High-tech manufacturing process
 

What is Lactobacillus salivarius?

From the name we can already deduce that Lactobacillus salivarius is a kind of bacteria that is present in our saliva. It is responsible for the proper metabolization of carbohydrates into organic acids, such as lactic acid and acetic acid. These important substances inhibit the growth and spread of pathogens and other microorganisms that can cause infections and diseases. L. Salivarius also produces hydrogen peroxide and other antimicrobial agents.

L. Salivarius is known for its ability to grow and spread rapidly. This helps to suppress harmful bacteria. In the human body L. Salivarius is present in the large intestine, small intestine, vagina and mouth. Lactobacillus salivarius is found in foods such as yogurt, tomatoes, bananas, chicory root, artichokes, garlic and asparagus. It is regularly taken as a supplement because it is often part of a probiotic mix.

There are numerous studies showing that L. Salivarius can help with many gastrointestinal problems such as diarrhoea caused by antibiotics, irritable bowel syndrome and lactose intolerance. There are even studies that clearly show that L. Salivarius has a beneficial effect on cholesterol levels. This probiotic also ensures that the immune system functions properly. And finally, L. Salivarius would be very useful for maintaining dental health.

 

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Why choosing Lactobacillus salivarius LS159?

Fermedics’ probiotics are manufactured to the highest standard and based on years of scientific research. Our patented probiotic strains are different from the others since all our probiotics are protected by a patented five-layer microencapsulation technology!

This 5-layer protection also has the following advantages:

  • major logistical advantages
  • probiotic strains also remain more stable in the capsule or sachet
  • no contamination / interaction with the filling system
  • a fluid powder that is easy to encapsulate

In general, only a few % of the probiotics sold can reach the intestines and this is very little. Most of them are dead before they’re consumed and the probiotics that are still alive, are eliminated by more than 60% through the intestinal juices.

 

Tests with probiotics subjected to 5-layer microencapsulation

The 5-layer protection significantly increases the stability and survival of probiotics and has many advantages compared to unprotected probiotics.

The tests clearly show that coated probiotics are resistant to stomach acid, bile salts and other digestive juices, allowing them to reach the intestine intact, which is not the case with unprotected probiotics. Improving the stability and protection against digestive juices of protected probiotics also means that a lower dosage per day is necessary (cost savings) because of the good protection (6 to10 billion bacteria is a good daily dosage).

Stability test shows that coated probiotics remain almost intact (loss of 7 to 8%) after the first 6 months of storage at room temperature, while uncoated probiotics lose nearly 80% of their activity, which is remarkable. Stability test at room temperature for 12 months shows that coated lactic acid bacteria (through patented 5-layer microencapsulation) are much more robust and stable than uncoated bacteria that have already lost much of their activity after 3 months, and after 6 months there is almost no activity, which is absolutely not the case with coated bacteria.

 

Improving storage stability of probiotics

Both uncoated and coated (by patented 5-layer microencapsulation) lactic acid bacteria were stored at 40 °C for four weeks. The result shows that the efficiency of lactic acid bacteria subjected to patented 5-layer microencapsulation is much better (more than 9 log).

 

Properties of Fermedics’ probiotics

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Health benefits

  • Preventing strep throat
  • Improving gastrointestinal function
  • Inhibiting candida
  • Liver protection
  • Reducing gingivitis
  • Reducing IBS
  • Reducing ulcerative colitis
  • Regulating the immune system
  • Treatment diarrhea caused by antibiotics

Storage condition

  • Transport is in refrigerated conditions. Therefore, it is preferable that the manufacturer of finished products keeps the raw material in refrigerated state until the beginning of production.
  • Frozen probiotics can easily be stored as a raw material for 2 years without having a significant effect on CFU/g. If probiotics are stored in the refrigerator at 4°C – 8°C, the storage time is also substantially better than at room temperature.
  • After production, probiotics in the package should also preferably be stored in the refrigerator between 4°C – 8 °C, as the result is always better for CFU/g.
  • As soon as the finished products leave the company for distribution to wholesalers and retailers, probiotics can be stored at room temperature (+/- 12 months) if the 25°C is not exceeded. This guarantees the consumer a quality product, even if stored at room temperature.
  • Expiry date: 18 months if the preservation conditions are applied as above.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA) and price quotation.

MOQ (minimum order quantity) 10 kg

Legislation

Lactobacillus salivarius belongs to the list of micro-organisms that have obtained Qualified Presumption of Safety (QPS) status, defined by EFSA in Europe (2007) because of their safe use in food (1).

(1) Annex II of Regulation (EU) No 1169/2011

SourceIncubation methodIdentification of microbePotencyFormRecommended daily dosage
plant picklesdeep-layer liquid state incubation16S rDNA gene sequencing1.0 x 1011 CFU/gpowder6.0 x 109

This probiotic is obtained by a fermentation process, freeze-dried and subjected to a patented five-layer microencapsulation technology to protect and preserve each individual probiotic strain optimally. It is a white to cream-coloured, free-flowing powder with high stability.

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References

  • D’Souza, A. L. et al. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 324
  • Dierksen KP, Moore CJ, Inglis M, Wescombe PA, Tagg JR. The effect of ingestion of milk supplemented with salivaricin A-producing Streptococcus salivarius on the bacteriocin-like inhibitory activity of streptococcal populations on the tongue. FEMS Microbiol Ecol. 2007 Mar;59(3):584-91.
  • Haukioja, A. Probiotics and Oral Health. European Journal of Dentistry.
  • Khalesi, S. et al. Effect of probiotics on blood pressure: a systematic review and meta-analysis of randomized, controlled trials. Hypertension. 64
  • Kumar, M. et al. Cholesterol-Lowering Probiotics as Potential Biotherapeutics for Metabolic Diseases. Experimental Diabetes Research.
  • O’ Hara. A. M. et al. Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius. Immunology. 118
  • Ortiz-Lucas, M. et al. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysi. Revista Española de Enfermedades Digestivas. 105.1 (4 Apr. 2013): 19–36. 8 Dec. 2016.
  • Rijkers, G.T. et al. Health benefits and health claims of probiotics: Bridging science and marketing. British Journal of Nutrition. 106
  • Sanders, M.E. Considerations for use of probiotic bacteria to modulate human health. The Journal of Nutrition. 130
  • Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, Hirata H. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebocontrolled study. J Clin Periodontol. 2008 Oct;35(10):897-905.