High-tech manufacturing process

What is Probio-S?

Probio-S consists of a complex of 3 types of probiotics: Bifidobacterium adolescentis BA286, Lactobacillus rhamnosus LCR177 and Pediococcus acidilactici PA318.

Consuming probiotics can really reduce your body weight and body mass index. Probiotics can also improve your blood sugar level and help regulate your appetite. Even this small weight reduction can reduce the risk of diseases such as type 2 diabetes and high blood pressure.

Research with Probio-S complex has shown that it stimulates weight loss, resulting in less body fat and a slimmer figure. Total cholesterol and triglyceride levels can also be lowered, creating a protective effect on the heart and blood vessels.


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Why choosing Probio-S?

Fermedics’ probiotics are manufactured to the highest standard and based on years of scientific research. Our patented probiotic strains are different from the others since all our probiotics are protected by a patented five-layer microencapsulation technology!

This 5-layer protection also has the following advantages:

  • major logistical advantages
  • probiotic strains also remain more stable in the capsule or sachet
  • no contamination / interaction with the filling system
  • a fluid powder that is easy to encapsulate

In general, only a few % of the probiotics sold can reach the intestines and this is very little. Most of them are dead before they’re consumed and the probiotics that are still alive, are eliminated by more than 60% through the intestinal juices.


Tests with probiotics subjected to 5-layer microencapsulation

The 5-layer protection significantly increases the stability and survival of probiotics and has many advantages compared to unprotected probiotics.

The tests clearly show that coated probiotics are resistant to stomach acid, bile salts and other digestive juices, allowing them to reach the intestine intact, which is not the case with unprotected probiotics. Improving the stability and protection against digestive juices of protected probiotics also means that a lower dosage per day is necessary (cost savings) because of the good protection (6 to10 billion bacteria is a good daily dosage).

Stability test shows that coated probiotics remain almost intact (loss of 7 to 8%) after the first 6 months of storage at room temperature, while uncoated probiotics lose nearly 80% of their activity, which is remarkable. Stability test at room temperature for 12 months shows that coated lactic acid bacteria (through patented 5-layer microencapsulation) are much more robust and stable than uncoated bacteria that have already lost much of their activity after 3 months, and after 6 months there is almost no activity, which is absolutely not the case with coated bacteria.


Improving storage stability of probiotics

Both uncoated and coated (by patented 5-layer microencapsulation) lactic acid bacteria were stored at 40 °C for four weeks. The result shows that the efficiency of lactic acid bacteria subjected to patented 5-layer microencapsulation is much better (more than 9 log).


Properties of Fermedics’ probiotics

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Health benefits

  • Cardiovascular protection
  • Lowering triglycerides and cholesterol 
  • Stimulating weight loss

Storage condition

  • Transport is in refrigerated conditions. Therefore, it is preferable that the manufacturer of finished products keeps the raw material in refrigerated state until the beginning of production.
  • Frozen probiotics can easily be stored as a raw material for 2 years without having a significant effect on CFU/g. If probiotics are stored in the refrigerator at 4°C – 8°C, the storage time is also substantially better than at room temperature.
  • After production, probiotics in the package should also preferably be stored in the refrigerator between 4°C – 8 °C, as the result is always better for CFU/g.
  • As soon as the finished products leave the company for distribution to wholesalers and retailers, probiotics can be stored at room temperature (+/- 12 months) if the 25°C is not exceeded. This guarantees the consumer a quality product, even if stored at room temperature.
  • Expiry date: 18 months if the preservation conditions are applied as above.

Technical properties

Fermedics offers you on request all technical data of this ingredient, such as Certificate of Analysis (COA) and price quotation.

MOQ (minimum order quantity) 10 kg


The probiotic strains in Probio-S belong to the list of micro-organisms that have obtained Qualified Presumption of Safety (QPS) status, defined by EFSA in Europe (2007) because of their safe use in food (1).

(1) Annex II of Regulation (EU) No 1169/2011

CompositionIncubation methodIdentification of microbePotencyFormRecommended daily dosage
Bifidobacterium adolescentis BA286
Lactobacillus rhamnosus LCR177
Pediococcus acidilactici PA318
deep-layer liquid state incubation16S rDNA gene sequencing1.0 x 1011 CFU/gpowder1.5 x 1010

The probiotic strains are obtained by a fermentation process, freeze-dried and subjected to a patented five-layer microencapsulation technology to protect and preserve each individual probiotic strain optimally. It is a white to cream-coloured, free-flowing powder with high stability.

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  • Hsueh-Fang Wang, Shu-E Lai, Cheng-Chih Tsai and Chung-Chia Liao. The Effect of Multi-Strain Probiotics Formula on Blood Pressure and Health Maintenance in Healthy Humans. J Nutr Diet 2018, 1:2
  • Lan, A., Hsieh, R.H., Tsai, C.C., & Huang, C.C. (2015) Effects of a probiotic preparation on the human faecal microflora and biochemical and haematological parameters. Science Asia, 41(3), 155-161
  • Lai, C.H., Tsai, C.C., Kuo, W.W., HO, T.J., Day, C.H., PAI, P.Y.; & Huang, C.Y. (2016). Multi-strain probiotics inhibit cardiac myopathies and autophagy to prevent heart injury in high-fat diet-fed rats. International Journal of Medical sciences, 13(4), 277.
  • Tsai, C.C., Chou, L.C., Lai, S.E., & Huang, C.C. (2016). Effect of cholesterol lowering multiplex lactic acid bacteria on lipid metabolism in a hamster model. African Journal of Microbiology Research, 10(20), 708-716